Cryoimmunotherapy

[D.ap]

https://en.m.wikipedia.org/wiki/Cryoimmunotherapy


Cryoimmunotherapy, also referred to as cryoimmunology, is an oncological treatment for various cancers that combines cryoablation of tumor with immunotherapy treatment.[1] In-vivo cryoablation of a tumor, alone, can induce an immunostimulatory, systemic anti-tumor response, resulting in a cancer vaccine - the abscopal effect.[2] Thus, cryoablation of tumors is a way of achieving autologous, in-vivo tumor lysate vaccine and treat metastatic disease.[3][4] However, cryoablation alone may produce an insufficient immune response, depending on various factors, such as high freeze rate.[5] Combining cryotherapy with immunotherapy enhances the immunostimulating response and has synergistic effects for cancer treatment.[6]

https://www.futuremedicine.com/doi/full ... imt.13.151

Cryoablation is increasingly being used as a primary treatment for localized cancers and as a salvage therapy for metastatic cancers. Anecdotal clinical reports and animal experiments have confirmed an induction of systemic antitumor immune response by tumor cryoablation. To capitalize on the stimulatory effects of cryoablation for cancer immunotherapy, this response must be intensified using other immunomodulatory agents. This article reviews the preclinical and clinical evidence and discusses the mechanism of the antitumor immune response generated by cryoablation. The rationale and evidence behind several immunotherapy approaches that can be combined with cryoablation to devise a cryoimmunotherapeutic strategy with a potential to impact the progression of metastatic disease are described.