Relevant Links

1. Our very own discussion forum with patient support and personal updates, and a library of research and more! We have over 100 ASPS patients around the world, plus an additional 400 in China we can contact. 
2. An Article from the Liddy Shriver Sarcoma Initiative Website
3. Journal article about ASPS history. 
4. Children’s Hospital Boston ASPS information page.
5. A patient tells her ASPS story – Alicia Parlette’s blog.
6. You can do your won research by reading peer reviewed literature. For example, here is a sample search on PUBMED. 
7. The Liddy Shriver Sarcoma Initiative undertakes activities that help improve the quality of life for people dealing with sarcoma. 
   

Relevant Scientific Publications 

Treatment options

• Value of repeat resections for survival in lung metastases from soft tissue sarcoma (Liebl et al. 2007)
• The new 1,318 nm Nd:YAG Laser system facilitates any kind of parenchymal lung resection in lobe sparing manner and in case of complete resection improves significantly the survival(Rolle et al. (1) 2006)
• Report: Surgeries for a total of 328 consecutive patients who had multiple lung metastases with a new 1318-nm Nd:YAG laser (Rolle et al. (2) 2006)
• Case studies of Alveolar Soft Part Sarcoma in MSKCC leads to the conclusion that practicing appropriate diagnostic techniques, aggressive surgical control of the primary tumor and long-term surveillance for metastases may result in long term survival (Kayton et al. 2006)
• Alveolar soft-part sarcoma responding to interferon alpha-2b (Roozendaal et al. 2003), case study.
• ASPS responds to intensive chemotherapy (Nickerson et al 2004), case study.
• Expression of Vascular Endothelial Growth Factor (VEGF) in ASPS and response to treatment with Avastin (bevacizumab) and interferon alpha-2b (Azizi et al. 2006), case study.
• ASPS Gene expression profiling of alveolar soft – part sarcoma (Stockwin et al 2009) 

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Potential ASPS Therapies

• TFE3 fusion gene activates MET signaling, indicating that ASPS is a target for therapeutic MET inhibition (Tsuda et al. 2007)
• Halofuginone for Alveolar Soft Part Sarcoma (Genin et al. 2008)

ASPS Clinical Studies

• Alveolar Soft Part Sarcoma: A Single-Center 26-Patient Case Series and Review of the Literature (Ogura et al. 2012)
• Alveolar Soft Part Sarcoma – An Italian Study (Casanova et al. 2000)
• Alveolar Soft Part Sarcoma – A Japanese Study (Ogose et al. 2003)
• Alveolar Soft Part Sarcoma – An American/ Texas Study (Portera et al. 2000)

The Genetics of Alveolar Soft Part Sarcoma

• The chromosomal translocation in Alveolar Soft Part Sarcoma creates fusion between two genes: ASPL-TFE3 (Ladanyi et al. 2001)
• ASPL-TFE3 fusion is involved in ASPS, but also in Renal Cancer (Argani et al. 2001)
• The translocation of ASPS occurs in G2 of the cell cycle (Huang et al. 2005)

Gene expression studies of ASPS tumors

• Staining of ASPL-TE3 in tumors of TFE3 fusions (Argani et al. 2003)
• Immunostaining of TFE3 as a tool in the diagnosis of Alveolar Soft Part Sarcoma (Miller, 2003)
• Angiogenesis – Promoting Gene Patterns in Alveolar Soft Part Sarcoma (Lazar et al. 2007)
• Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of Alveolar Soft Part Sarcoma (Vistica et al. 2008)

June 2006: The cancer inducing activity of the gene MITF is demonstrated in clear cell sarcoma

This finding suggests that MITF and possibly other MITF related genes: TFE3, TFEB and TFEC serve as “oncogene engines” to induce cancer formation. TFE3 is the translocated gene, which is found in alveolar soft part sarcoma. Click here to read a commentary in EurekAlert. The original study was published in the Cancer Cell journal: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers