Keto diets shrink pancreatic and colorectal tumors by starving them of the glucose they need to survive. But they also speed up development of a lethal wasting disease called cachexia. In mice, CSHL researchers have found that pairing keto with a corticosteroid prevents cachexia and increases survival.
Dietitians say a keto diet could help you lose up to 10% of your body weight. These high-fat, low-carb meal plans trick the body into burning its own fat. They could also help fight a variety of cancers by starving tumors of the glucose they need to grow. On the surface, this seems ideal. But research suggests these diets may have a deadly, unintended side effect for cancer patients.
https://www.cshl.edu/the-latest-weapon- ... keto-diet/
Tackling the Conundrum of Cachexia in Cancer
Re: Tackling the Conundrum of Cachexia in Cancer
One of the worst cruelties of lethal cancer is the phenomenon called wasting, or in medical terms, cachexia (pronounced ka-CHEX-ia), in which a patient seems literally to diminish in bodily terms as the cancer ravages one or more internal organs.
Today, a team at Cancer Research UK Cambridge Institute, led by Professor Douglas Fearon, M.D., of Cold Spring Harbor Laboratory in New York and a Distinguished Scholar of the Lustgarten Foundation, publishes in Cell Metabolism results of experiments showing that tumors interfere with the patient’s ability to cope with wasting and may even impair their ability to respond to immunotherapy.
https://www.cshl.edu/pancreas-and-colon ... -response/
Today, a team at Cancer Research UK Cambridge Institute, led by Professor Douglas Fearon, M.D., of Cold Spring Harbor Laboratory in New York and a Distinguished Scholar of the Lustgarten Foundation, publishes in Cell Metabolism results of experiments showing that tumors interfere with the patient’s ability to cope with wasting and may even impair their ability to respond to immunotherapy.
https://www.cshl.edu/pancreas-and-colon ... -response/
Debbie
Re: Tackling the Conundrum of Cachexia in Cancer
Tackling the Conundrum of Cachexia in Cancer cont…
The researchers in Cambridge, led by M.D.-Ph.D. student Thomas R. Flint and oncologist Tobias Janowitz, M.D., Ph.D., performed experiments demonstrating that in mouse models of pancreas and colon cancer, liver reprogramming begins during pre-cachexia, when wasting has just begun but is not yet manifest. Signals broadcast by tumor cells induce the release of interleukin 6 (IL-6), a molecular beacon of the immune system called a cytokine, that normally helps induce an immune response. IL-6, in turn, impairs the capacity of the liver to respond to caloric deprivation, which is already underway in pre-cachectic mice.
The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities
https://www.mdpi.com/2073-4409/11/22/36 ... 33%2C34%5D.
The researchers in Cambridge, led by M.D.-Ph.D. student Thomas R. Flint and oncologist Tobias Janowitz, M.D., Ph.D., performed experiments demonstrating that in mouse models of pancreas and colon cancer, liver reprogramming begins during pre-cachexia, when wasting has just begun but is not yet manifest. Signals broadcast by tumor cells induce the release of interleukin 6 (IL-6), a molecular beacon of the immune system called a cytokine, that normally helps induce an immune response. IL-6, in turn, impairs the capacity of the liver to respond to caloric deprivation, which is already underway in pre-cachectic mice.
The Role of IL-6 in Cancer Cell Invasiveness and Metastasis—Overview and Therapeutic Opportunities
https://www.mdpi.com/2073-4409/11/22/36 ... 33%2C34%5D.
Debbie