Histological analysis suggests an invasion-independent meta

[D.ap]

I was curious about a statement that Lynette had said about her husband Georges tumors :

Re: Ivan rocking it since 2003

Postby Jorge » Tue Aug 26, 2014 6:53 am

Olga,

I want to add some other points here:

In George's, ASPS mets usually don't grow in where they are close to. He had lung mets next to the chest wall, ribs and heart. We were told before surgery that there could be chance to operate on the adjacent organt if they are involved by ASPS. Finally it turt out none of these organs were involved. The ASPS mets are usually growing independtly, like George's brain mets.

Found this link on a study of ASPS tumors and their propisity to not invade near by tissues but be blood borne and metastize??

Histological analysis suggests an invasion-independent metastatic mechanism in alveolar soft part sarcoma.
Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor characterized by pseudoalveolar growths associated with abundant sinusoidal vessels. It has a high proclivity to blood-borne metastasis, but the exact mechanism of spread has not been widely discussed, and detailed histological analysis of vascular involvement is still lacking. In this study, we histologically analyzed 32 surgically resected ASPSs, with particular attention to the mode of vascular involvement. Among 188 instances of unequivocal vascular involvement, 184 (98%) were in the form of variously sized cohesive clusters that were completely enveloped by endothelial cells, confirmed by CD31 immunostaining. Discohesive intravascular tumor cells without endothelial wrapping were rare (2%). The clinical relevance of vascular involvement was supported by survival analysis where the average number of vascular involvements per slide was an independent risk factor for shorter progression-free survival. Our findings suggest that ASPSs do not actively break through the vascular walls to initiate the metastatic process. They instead suggest that ASPSs almost exclusively follow the recently postulated "invasion-independent mechanism" for entry into circulation, in which cancer cells are shed into vessels, while being completely enveloped by endothelial cells, and are subsequently entrapped at recipient organs. Because the latter mechanism is reportedly dependent on tumor angiogenesis and vascular remodeling, our data provide a morphological rationale for the use of anti-angiogenic therapy to treat ASPSs.

http://www.ncbi.nlm.nih.gov/pubmed/24321522
Does this mean encapsulated ?
Night all

[D.ap]

Another study of 32 ASPS tumors

Histological analysis suggests an invasion-independent metastatic mechanism in alveolar soft part sarcoma ☆
Nokitaka Setsu MD, PhDAkihiko Yoshida MD, PhDRyoji Kushima MD, PhD

Summary
Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor characterized by pseudoalveolar growths associated with abundant sinusoidal vessels. It has a high proclivity to blood-borne metastasis, but the exact mechanism of spread has not been widely discussed, and detailed histological analysis of vascular involvement is still lacking. In this study, we histologically analyzed 32 surgically resected ASPSs, with particular attention to the mode of vascular involvement. Among 188 instances of unequivocal vascular involvement, 184 (98%) were in the form of variously sized cohesive clusters that were completely enveloped by endothelial cells, confirmed by CD31 immunostaining. Discohesive intravascular tumor cells without endothelial wrapping were rare (2%). The clinical relevance of vascular involvement was supported by survival analysis where the average number of vascular involvements per slide was an independent risk factor for shorter progression-free survival. Our findings suggest that ASPSs do not actively break through the vascular walls to initiate the metastatic process. They instead suggest that ASPSs almost exclusively follow the recently postulated “invasion-independent mechanism” for entry into circulation, in which cancer cells are shed into vessels, while being completely enveloped by endothelial cells, and are subsequently entrapped at recipient organs. Because the latter mechanism is reportedly dependent on tumor angiogenesis and vascular remodeling, our data provide a morphological rationale for the use of anti-angiogenic therapy to treat ASPSs.

Keywords
Alveolar soft part sarcomaInvasionMetastasisAngiogenesis

Fig. 1.
Table

Table.

Fig. 2.
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Conflicts of interest and source of funding: The authors declare no conflict of interest. This work was supported in part by the National Cancer Center Research and Development Fund (23-A-10, 23-B-12).

http://www.sciencedirect.com/science/ar ... 7713003699