Gradual release of immunotherapy at site of tumor surgery. Mouse study.

[arojussi]

I saw this around a moth ago. I think it was in asps facebook group, but could have been somewhere else as well. It just hit me why this might be interesting for asps community, if they ever start to test this in asps. First of all asps main treatment is surgery. Immunotherapies also seems to work well in asps . Nobody knows why at the moment. Surgery indeed forces immunesystem to focus on found healing and this new approach might in theory prevent rebound effect after surgery. Also this is not pd1-inhibitor, so trying it, shouldnt prevent keytruda treatment in the future if neccessery. If my memory serves me correcty dendritic cell vaccine wasnt very succesfull, but this is different approach that might achieve different result. Main reason why I post this, is because if they ever start to test this in asps I want to be able to say, that I believed it was a good idea. If this fails or leads to nowhere then this is just one more stubid thing that I posted on the internet. Allhttp://www.dana-farber.org/newsroom/news-relea ... use-study/ Gradual release of immunotherapy at site of tumor surgery prevents tumors from returning and eliminates cancer spread in mouse study

[D.ap]

Jussi

Think it sure sounds interesting , not EVER insignificant to share .. thank you for sharing :)

Is this the article ?

Couldn’t get the link to work

https://www.sciencedaily.com/releases/2 ... 141420.htm

[arojussi]

Yes it looks like the right article.

[D.ap]

Jussi
It’s excellent news when cancer can be stopped at any stage, I feel.

Maybe understanding how ASPS becomes metastic
disease . Is it thru the blood or lymphatic system or both, and this answer would give us a better direction to whether this technique of “gel treated immune Med “ being beneficial with the removal of an ASPS tumor.


Although , the immunological programming that is started by the surgery plus immune Med gel, is exciting .
Immune reprogrammed type memory cells ..

From the article

“The goal of the new approach is to convert that immunosuppressive ,( which it points out is surgery creates immosuppression) ,environment into an "immunostimulatory" one, Goldberg says -- a condition in which the immune system is primed for an offensive against cancer cells.”

What do you see as a possible benefit ?

I looked at articles talking of disemmentation of cells from the primary and found this

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459485/

“Lymphatic or Hematogenous Dissemination: How Does a Metastatic Tumor Cell Decide?”

I feel this is important thought to talk thru..

Night state side
Debbie

[D.ap]

Jussi
Regardless of dissemination process
(vascular or lymphatic ) I would venture to say that the gel could possibly put into action a positive process of memory cells to cause the immune system to attack any possible further metastatic tumors as it is creating an antigen specific marker for future T cell recruitment, associated to the primary ?


Tumor immunosuppressive environment: effects on tumor-specific and nontumor antigen immune responses.

https://www.ncbi.nlm.nih.gov/m/pubmed/19761435/