New clinical trial for ASPS is expected to open on March 2016.
This is a phase II clinical trial that combines treatment with Axitinib and Pembrolizumab in patients with advanced Alveolar Soft Part Sarcoma (ASPS) and other soft tissue sarcomas.
Axitinib (AG013736; trade name Inlyta) is a small molecule tyrosine kinase inhibitor.
Pembrolizumab (formerly MK-3475 and lambrolizumab, trade name Keytruda) is an antibody used in cancer immunotherapy to target the programmed cell death 1 (PD-1) receptor.
Patients will be treated with twice daily dosing of axitinib alone for the first 7 days, followed by concurrent axitinib administered twice daily at 5 mg orally (PO), plus intravenous administration of pembrolizumab every 21 days. Patients will be assessed every three weeks for toxicity.
The study will include up to 30 patients
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Contact information:
Breelyn Wilky, MD, University of Miami
Phone: 305-243-1287
e-mail: b.wilky@med.miami.edu
_____________________________________________________
Yosef Landesman, Ph.D.
President & Cancer Research Director
Cure Alveolar Soft Part Sarcoma International (iCureASPS)
e-mail: landesmany@yahoo.com