Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases?

[D.ap]

Does immunotherapy increase the rate of radiation necrosis after radiosurgical treatment of brain metastases?


OBJECT
Radiation necrosis (RN), or its imaging equivalent, treatment-related imaging changes (TRIC), is an inflammatory reaction to high-dose radiation in the brain. The authors sought to investigate the hypothesis that immunotherapy increases the risk of developing RN/TRIC after stereotactic Gamma Knife (GK) radiosurgery for brain metastases.


CONCLUSIONS
Patients who receive IT alone may have an increased rate of RN/TRIC compared with those who receive CT or TT alone after stereotactic radiosurgery, whereas receiving any CT may in fact be protective against RN/TRIC. As the use of immunotherapies increases, the rate of RN/TRIC may be expected to increase compared with rates in the chemotherapy era.



https://thejns.org/view/journals/j-neur ... le-p17.xml