Papers about ASPS origination

[D.ap]

I was under the impression that ASPS was a muscle sarcoma?
I was reading this paper written in 1992 that suggest a nerve origination?

Cancer. 1992 Nov 15;70(10):2444-50.

Molecular genetic, cytogenetic, and immunohistochemical characterization of alveolar soft-part sarcoma. Implications for cell of origin.

Cullinane C1, Thorner PS, Greenberg ML, Kwan Y, Kumar M, Squire J.

Author information

Abstract

BACKGROUND:

Alveolar soft-part sarcoma is a rare tumor of uncertain histogenesis.

METHODS:

The authors report a patient who was studied using immunohistochemistry, cytogenetic analysis, and molecular probes for MyoD1 and MYCN (N-myc proto-oncogene).

RESULTS:

By immunoperoxidase, the tumor was focally positive for vimentin, neuron-specific enolase, and S-100 protein but negative for muscle-specific actin, desmin, and low-molecular-weight keratin. Direct chromosome analysis of primary tumor cells using G-banded preparations yielded two clonally abnormal lines: one demonstrated trisomy 47,XX+5; the other demonstrated 46,XX,1p-,17q+. Expression of the MYCN RNA was detectable at a low level, and MYCN was single copy at the DNA level. Expression of the myogenic molecular marker MyoD1 was not detected by Northern blotting analysis.

CONCLUSIONS:

This is the first detailed study to address the molecular biology and tumor cytogenetics of alveolar soft-part sarcoma. The results of this study indicate a neurogenic origin for this unusual tumor and fail to provide support for the notion of a myogenic origin.


PMID: 1423174 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm.nih.gov/pubmed/1423174

[D.ap]

Or is it skeletal?


Abstract

In 1952, Christopherson et al. proposed that alveolar soft-part sarcoma (ASPS) was a distinct entity with unique clinical and pathological features. Since their report, its histogenesis has not been determined. In order to clarify the histogenesis of ASPS, a study using reverse transcription polymerase chain reaction using cDNAs from MyoD1 and myogenin, and the actin filament from human-skeletal-muscle-related mRNAs has been performed in 5 cases of ASPS. The expression of MyoD1 and myogenin was determined in 5 and 2 cases of the 5 cases, respectively. Moreover, expression of the many mRNAs from the actin filament of skeletal muscle was also found in ASPS. According to these findings, it is now postulated that ASPS is of skeletal muscle origin.

Copyright 2000 S. Karger AG, Basel







http://www.ncbi.nlm.nih.gov/pubmed/10838498