Need for awareness & vigilance regarding possible rebound

[Bonni Hess]

Dear ASPS Community Members,
Through the shared experiences, updates, and my private communications with ASPS patients who were previously participating in a Cediranib Clinical Trial and then unfortunately developed resistance to the Cediranib, it has become very evident that rapid and aggressive rebound and disease progression can/does sometime occur following discontinuation of the Cediranib. Based on this very concerning anecdotal data, I feel that it is extremely important that everyone who is currently taking Cediranib be very aware of the possibility of rebound, and that they have a plan in place to begin another systemic treatment as soon as possible after discontinuing the Cediranib if that becomes necessary, to try to prevent the rapid and aggressive post-Cediranib disease progression that has devastatingly been experienced by several ASPS patients on this Board.
It is critically important to everyone in the ASPS Community who is closely following this promising drug, for all of the ASPS patients or family members of ASPS patients who have previously taken, or are currently taking Cediranib to write to share their Cediranib treatment experience, results, and any anecdotal information regarding rebound experience. None of us have the luxury of waiting for all of the Cediranib Clinical Trial data to be gathered, documented, and published in an official report, which sometimes can take several years, so the best and most up-to-date information that is currently available to all of us must come from shared indivdual patient experience.
Take care everyone, and please try to actively participate on the Board with updated shared information as your time and situation allow.
With special concern, caring thoughts, and continued Hope,
Bonni