Chemotherapy works better after acquired TKI resistance

[Olga]

We recently discuss a lot the situation when there is an accrued resistance to some of the TKI drugs, either on clinical trials or off label, so when I came across this article I thought it might be interesting to read:

Subsequent chemotherapy improves survival outcome in advanced non-small-cell lung cancer with acquired tyrosine kinase inhibitor resistance.
http://www.ncbi.nlm.nih.gov/pubmed/20085868
They speak about the different type of the TKI - Epidermal growth factor receptor (EGFR) and the cancer is non-small-cell lung cancer, but may be some type of this effect exists in ASPS too, just a hypothesis.