Complete Remission of Lung Mets in RCC after immunoterapy

[Olga]

Complete Remission of Lung Metastasis Following Adoptive Immunotherapy Using Activated Autologous γδ T-cells in a Patient with Renal Cell Carcinoma
Abstract. Background: γδ T-cells have recently attracted
considerable attention in the development of novel cancer
immunotherapy, and several different approaches have been
designed and employed in clinical trials. Case Report: A
patient with lung metastasis after radical nephrectomy for
renal cell carcinoma had six cycles of adoptive
immunotherapy using autologous in vitro-activated γδ Tcells
followed by low-dose interleukin-2 and zoledronic acid
intravenous infusion. Complete remission was achieved
which has been maintained for 2 years without any
additional treatment. Immunological analysis demonstrated a
high level of interferon-gamma four hours through one day
following the transfer and peripheral blood γδ T-cells
increased 10-fold from the baseline value, 7 days after the
transfer. No serious adverse events were observed.
Conclusion: Adoptive immunotherapy using γδ T-cells was
shown here to be clinically beneficial and safe, and may
become a therapeutic option for patients with advanced
RCC

[Olga]

The original article is from Tokyo, but according to some additional info from the SA mailing list, Dr. Raymond Chang, NYC has written about this a
while back and offers this off label modality to patients - I am not sure if the treatment is exactly the same, it is not verified by me or anyone on the board.

http://cancerx.wordpress.com/2009/02/23 ... for-cancer

He states that it is a very simple infusion procedure done once a month.

[Fictional]

Very cool. But IL-2 can be pretty toxic.