Saskia Dx April 2019 - on Cabozantinib since May 2019

[D.ap]

Hello Saskia ,

Good to know there is a plan to remove the primary .
As ASPS is so incredibly vascular make sure that you consult a sarcoma surgeon .
Also along with helping to “normalize “ the unregulated mass of tumor, the TKI can cause bleeding problems as it is an anti-vascular medicine . So the planning for needs to include going off the tki.

Also as renal cell carcinoma , one of the cancers using cometriq , has a lot of similarities to ASPS in how and where it metastasizes I suspect it truly could help in the lungs and primary . Time will tell.

I assume you mean radiation to the primary when you say radiation and Tki?

[Saskia]

Hello Debbie,

Prof. Dr. Schwarzbach is a sarcom surgeon specialist in Germany.
Yes sorry I meant radiation on the primary tumor in my leg additionaly to taking TKI.

Big hugs,
Saskia

[D.ap]

Saskia

Great news !

So with that understanding , has he given you any data that indicates that cometriq and radiation would benefit the Asps in your leg tumor reduction ?


As ASPS is radio resistant and immune suppressive meds exacerbate and can result in grow , immunotherapies have been proven time and time again to work better with radiation .
The abscopsal effect its called. It can create the same systemic affect as a tki.
The clinical trial of axitinib and Keytruda her in USA has proven for the most part to of shown much progress with ASPS.
I’m not sure of using radiation with just cometriq would be good idea at all on your leg tumor .

[D.ap]

Saskia

Study of using tki verses immunotherapy
And or combination ( triad) at a molecular level

“Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339950/