Gastric acid suppressants reduce TKI positive treatment effect

[Olga]

This is the article From ASCO re. Gastric Acid Suppressants and Pazopanib negative interaction - we can safely assume the interaction with the other TKI would be the same.

Gastric Acid Suppressants May Reduce Survival Outcomes in Patients With Sarcoma Treated With Pazopanib

A study investigating whether gastric acid suppressive agents negatively impact the effectiveness of pazopanib in patients with soft-tissue sarcoma found that the long-term use of gastric acid suppressive therapy with pazopanib was associated with significantly shortened progression-free survival and overall survival. The report by Mir et al was published in Clinical Cancer Research.

http://www.ascopost.com/News/59754?emai ... c004b5ef5a <http://www.ascopost.com/News/59754?ema>

[D.ap]

Hi Olga
I wonder what is safe to be prescribe for patients in need of stomach acid reflux relief ?
We’ve had a lot of prior folks have this issue and it still happens .:(
My grand parents have to me , oh “cough “years ago

https://www.healthline.com/health/diges ... cid-reflux

[Olga]

I do not know what the safer combinations are, but probably being on a diet that reduce a gastric acid secretion would help from the other end

[D.ap]

Yes I think that would be a start.
I have IBS.

It can lead to acid reflux .

https://www.everydayhealth.com/ibs/livi ... -gerd.aspx


Caffeine reduction is a necessary evil .:/