Case of pembrolizumab-induced myocarditis in ASPS
Posted: Mon Sep 07, 2020 11:39 pm
Case of pembrolizumab-induced myocarditis presenting as torsades de pointes with safe re-challenge
https://pubmed.ncbi.nlm.nih.gov/32089073/
To the best of our knowledge, this is the first reported case of successful re-challenge of pembrolizumab after an episode of myocarditis. In patients with mild myocarditis and no evidence of left ventricular dysfunction, re-challenge may be a viable option. However, close monitoring for the development of heart failure, cardiomyopathy, or serious arrhythmias is necessary to ensure patient safety.
https://pubmed.ncbi.nlm.nih.gov/32089073/
To the best of our knowledge, this is the first reported case of successful re-challenge of pembrolizumab after an episode of myocarditis. In patients with mild myocarditis and no evidence of left ventricular dysfunction, re-challenge may be a viable option. However, close monitoring for the development of heart failure, cardiomyopathy, or serious arrhythmias is necessary to ensure patient safety.