TECENTRIQ (atezolizumab) Auz and Tom

[Olga]

Thank to our member, we now have an information about the good response to another PD-L1 immunotherapy drug on a market - TECENTRIQ (atezolizumab) by Genentech, Roche's subsidiary.
The patient Auz from Toronto - Dx May 2015 at 19 yo is participating in a clinical trial ClinicalTrials.gov Identifier: NCT02458638
view here:
https://clinicaltrials.gov/ct2/show/NCT02458638
reposted from here:
http://www.cureasps.org/forum/viewtopic ... 9907#p9907
It is now approved for the advanced urothelial carcinoma (mUC) or non-small cell lung cancer (NSCLC) in US, but It could probably be prescribed for ASPS off label if there are no other treatment options available and based on a response our patient is having.
It is still preferable to get the drug on a trial versus off label if possible so the response is properly documented and the patient gets proper side effects care as they might be not that well known by now.
There is also pediatric arm open as a separate clinical trial:
ClinicalTrials.gov Identifier: NCT02541604
https://clinicaltrials.gov/ct2/show/study/NCT02541604
Also open in China and other countries.
There are also numerous combination trials open with this drugs but it is hard to say which one could be appropriate for ASPS in aim to improve its efficiency.

[Olga]

I am reposting from Kathy FB page - Tom's update from Dec.6, 2018 re. his atezolizumab (TECENTRIQ) clinical trial at UPMC in Pittsburg:

After being on an immunotherapy trial for 18 months, he continues to have success. Tumors have disappeared, others have stayed the same and nothing new has grown. God has blessed us every step of the way. We are so thankful for our friends and family for helping us through. Our family would also like to thank Dr. Burgess at UPMC for making Alveolar Soft Part Sarcoma, as well as other rare cancers, her priority.

[D.ap]

Thank you Olga

Kathy and Tom ,
So incredibly happy to hear of continued success !
How big is the largest tumor being seen at this time?

Happy happy holidays!
Love
The Pearson’s

[Olga]

I think Kathy does not read here. I posted the same in Tom's personal topic, you might want to ask there.