Cure Alveolar Soft Part Sarcoma International (iCureASPS)

This topic is intended to collect the increasingly convincing body of evidence that combining some kind of SBRT for the brain metastases (basically any types of it - Novalis, GammaKnife, CyberKnife - as long as it is focused and high dose radiosurgery versus WBRT that is not effective in ASPS due to its radio-resistance) with immune checkpoint inhibitors improve both and provides a synergy, providing the better result that the radiosurgery and the ICI alone.

Concurrent Immune Checkpoint Inhibitors and Stereotactic Radiosurgery for Brain Metastases in Non-Small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma.
https://www.ncbi.nlm.nih.gov/pubmed/29485071
CONCLUSIONS:
Delivering SRS-SRT with concurrent ICI may be associated with a decreased incidence of new BMs and favorable survival outcomes without increased rates of adverse events.

Adverse Radiation Effect and Disease Control in Patients Undergoing Stereotactic Radiosurgery and Immune Checkpoint Inhibitor Therapy for Brain Metastases.
https://www.ncbi.nlm.nih.gov/pubmed/30902777
CONCLUSIONS:
Concurrent SRS-ICI therapy has a tolerable adverse event profile and may improve extracranial disease control and overall survival, supporting concurrent use in the management of BMs.