Cure Alveolar Soft Part Sarcoma International (iCureASPS)

D.ap wrote:Martin,

PROVISIONAL precludes the final report I think?
And maybe that PROVISIONAL is only to the staging?
Anyway what the location was?
And you were 31 years old and the dx was what date?
Thank you
There could maybe somehow be a format that we could all just fill in the blanks ?
Easier to the eye and an easier read?
Anyone have any thoughts ?
Debbie

Good day for all, I hope you are perfectly well, my result of pathology also referred to a tumor with a very low mitosis and an absent necrosis, I remember also that pathology explained to me that there were not many blood vessels feeding the tumor.
My question for you is,Good day for all, I hope you are perfectly well, my result of pathology also referredo to a tumor with a very low mitosis and an absent necrosis, I remember also that pathology explained to me that there were not many blood vessels feeding the tumor.
My question for you is,
The low mitosis and absent necrosis, as well as the removal of the tumor of a small size (15mm * 8mm) with negative surgical limits, (T1A N0 M0) really represents something good?
Are there ASPS less aggressive than others and if so, could this be my case?
I know that I am asking too much, but I am really confused and very scared, and in a week I will have a CT scan and my faith tells me that everything will be fine with the help of God.
But so much that I read on the Internet to create a world in my mind and that has terrified me.
But regardless of the result, I want God to bless you and to continue to help you.
The low mitosis and absent necrosis, as well as the removal of the tumor of a small size (15mm * 8mm) with negative surgical limits, (T1A N0 M0) really represents something good?
Are there ASPS less aggressive than others and if so, could this be my case?
I know that I am asking too much, but I am really confused and very scared, and in a week I will have a CT scan and my faith tells me that everything will be fine with the help of God.
But so much that I read on the Internet to create a world in my mind and that has terrified me.
But regardless of the result, I want God to bless you and to continue to help you.

D.ap wrote:

Good day for all, I hope you are perfectly well, my result of pathology also referred to a tumor with a very low mitosis and an absent necrosis, I remember also that pathology explained to me that there were not many blood vessels feeding the tumor.
My question for you is,Good day for all, I hope you are perfectly well, my result of pathology also referredo to a tumor with a very low mitosis and an absent necrosis, I remember also that pathology explained to me that there were not many blood vessels feeding the tumor.
My question for you is,
The low mitosis and absent necrosis, as well as the removal of the tumor of a small size (15mm * 8mm) with negative surgical limits, (T1A N0 M0) really represents something good?
Are there ASPS less aggressive than others and if so, could this be my case?
I know that I am asking too much, but I am really confused and very scared, and in a week I will have a CT scan and my faith tells me that everything will be fine with the help of God.
But so much that I read on the Internet to create a world in my mind and that has terrified me.
But regardless of the result, I want God to bless you and to continue to help you.
The low mitosis and absent necrosis, as well as the removal of the tumor of a small size (15mm * 8mm) with negative surgical limits, (T1A N0 M0) really represents something good?
Are there ASPS less aggressive than others and if so, could this be my case?
I know that I am asking too much, but I am really confused and very scared, and in a week I will have a CT scan and my faith tells me that everything will be fine with the help of God.
But so much that I read on the Internet to create a world in my mind and that has terrified me.
But regardless of the result, I want God to bless you and to continue to help you.

Andres
A lot of the SEER stats say you have much going for your future prognosis . : )

“Medical Definition of SEER. SEER: The Surveillance, Epidemiology, and Ends Results (SEER) program that maintains statistics on cancer in the US. SEER is part of the National Cancer Institute.”

In reference to sarcomas in general it’s stated

“This behavior is best predicted by the histologic grade, which is determined by 4 factors: mitotic index, degree of cellularity, necrosis when present, and degree of nuclear anaplasia.”

https://www.ncbi.nlm.nih.gov/pmc/articl ... po=13.5417
And as far as ASPS goes , this was a 40 year ? Study


Search -“Prognostic Factors in Alveolar Soft-Part Sarcoma: A SEER Analysis”

H. Wang, A. Jacobson, D. Harmon, J. Michaelson, T.F. DeLaney, Y. Chen
PlumX Metrics

Conclusions: In conclusion, our SEER-based study has identified a subset of 216 patients with ASPS in which the 5-year OS rate is 57% (95% CI 50- 64%). Older age, male sex, large tumor size of >10cm, distant metastasis at diagnosis, and trunk as primary tumor site are identified as negative pre- dictors of survival. The use of radiation with surgery does not significantly impact survival rates. Because SEER is limited by lack of data concerning local control and adjuvant chemotherapy, Medicare-linked SEER datasets and detailed cohort studies are in need to further treatment options for ASPS and to address the role of adjuvant radiation therapy and chemotherapy. Author Disclosure: H. Wang: None. A. Jacobson: None. D. Harmon: None. J. Michaelson: None. T.F. DeLaney: None. Y. Chen



However never forget that you have ASPS and always keep on a scan schedule .



.

MartinBube wrote: ↑Sun Apr 05, 2015 3:50 am Hi Debbie,

this is my report, it is little bit longer but i short term:
Vascular invasion can be seen
There is rarely seen atypical single mitosis up to one / 10HPF.
it is true that mitosis can be higher and lower. As I was told this that I have very low, but we will see in the future if that does make any difference.


PROVISIONAL REPORT: ALVEOLAR SOFT PART SARCOMA
Stage 1A (IF N0 M0)
T1b N? M?
DESCRIPITION OF THE TISSUE:
Post-operatively the oval fragment is weighing 10gr and has a size of 3x2.8x1.8 cm. The consistency is medium-hard and small nodules can be seen in a part of it. The colour is white to grey. In the periphery there is connective and lipid tissue and in small areas part of a muscle.
MICROSCOPY:
The tumor is built of large, uniform Epithelioid-like cells with rich eosinophilic and granulated cytoplasm. They are arranged in solid nests and alveolar structures, parted with gentle connective and vascular channels (tracks). Also there are rough-looking collagen septa with bigger blood vessels. There is a relatively clear demarcation from the surrounding structures of lipid and muscle tissue, but in certain areas there is evident infiltration of small and big tumorous nests in them. The tumorous population has relatively monomorphic big nuclei and some of them contain single eosinophilic nucleoli. There are some rare cytoplasmic nucleic inclusions. In certain zones there are mildly atypical and polychromatic nuclei. There is rarely seen atypical single mitosis (up to one / 10HPF). In the peripheral parts and the septal structures of the tissue vascular tumorous invasion can be seen.
The histochemical analysis with standard colouring is PAS negative.
Immunohistochemical analysis profile: NSE (+), Vimentin (+/- focally), Actin (+/- focally), CD117 (+/- disperse single cells), CD30 (-), CK7 (-), CK AE1/AE3 (-), CKWS (-), EMA(-), RCC (-), PLAP (-), Desmin (+/- focally), Synaptophysin (-), Chromogranin (-), S-100 protein (-), Melan A (-) and HMB45 (-).
Ki-67 shows variable proliferative index between 2% and 6% with a median value of 4%.
According to the described morphology and the above analyses the findings are described as alveolar soft part sarcoma.