Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Fentanyl buccal soluble film (FBSF) for breakthrough pain in patients with cancer: a randomized, double-blind, placebo-controlled study
http://annonc.oxfordjournals.org/cgi/reprint/mdp541v1

Background: Fentanyl buccal soluble film (FBSF) has been developed as a treatment of breakthrough pain in opioid-tolerant patients with cancer. The objective of this study was to evaluate the efficacy of FBSF at doses of 200–1200 µg in the management of breakthrough pain in patients with cancer receiving ongoing opioid therapy.
Patients and methods: This was a multicenter, randomized, double-blind, placebo-controlled, multiple-crossover study that included opioid-tolerant adult patients with chronic cancer pain who experienced one to four daily episodes of breakthrough pain. The primary efficacy assessment was the sum of pain intensity differences at 30 min (SPID30) postdose.
Results: The intent-to-treat population consisted of 80 patients with ≥1 post-baseline efficacy assessment. The least-squares mean (LSM ± SEM) of the SPID30 was significantly greater for FBSF-treated episodes of breakthrough pain than for placebo-treated episodes (47.9 ± 3.9 versus 38.1 ± 4.3; P = 0.004). There was statistical separation from placebo starting at 15 min up through 60 min (last time point assessed). There were no unexpected adverse events (AEs) or clinically significant safety findings.
Conclusions: FBSF is an effective option for control of breakthrough pain in patients receiving ongoing opioid therapy. In this study, FBSF was well tolerated in the oral cavity, with no reports of treatment-related oral AEs.

Thought this to be a good article for any care taker or patient to know post surgery
Surgey can certainly bring this breakthrough pain up close and personel to all involved
Fentanyl is mentioned as a long lasting opiod?

http://www.healthcentral.com/chronic-pa ... reak-pain/

Debbie

Dear ASPS Community members,
For the past several years Brittany has been using an oral Fetanyl bucal "lollipop" on a daily basis for her severe chronic post-op spinal pain and it is one of the few pain meds which provides her with any pain relief. However, it is important to be aware that constant use of the "lollipop" can cause significant tooth decay because in addition to the Fetanyl the "lollipop" contains a large amount of sugar. As a result, Brittany now heartbreakingly has several large cavities requiring root canals and extensive dental treatment .
With special caring thoughts and continued Hope,
Bonni

Bonni

You probably know this but hard candy ie lollipops chip enamel on the teeth and leave an opening for the bacteria to enter into . Lots of brushing and mouth wash and no sticky candy helps
I know Brittany. Easier said than done.
Thanks for the warning tho

Love
Debbie

Ps. Sorry. GO DENVER BRONCOS

Hello again Debbie,
Actually the Fetanyl bucal "lollipop" doesn't chip the teeth because it is swabbed around the inside of the cheek rather than being bitten and chewed on on with the teeth. The main issue is the amount of sugar contained in the "lollipop" and the effect that constant and continued use of the sugary "lollipop" as in Brittany's situation has on eroding the enamel of the teeth.
With special caring thoughts and continued Hope,
Bonni
GO SEAHAWKS!! Game on Broncos!!