Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Some time ago, I had sent an emal to Dr.Bharath Aggarwal frm MDAnderson, asking him if he had any experience on ASPS and curcumin. He didn't have anything specfic on ASPS, but sent me a list of articles on Curcumin and sarcoma. This is a lot of information for me, but maybe someone else here can understand it better. Here goes-
1.
Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers.
Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG.
J Agric Food Chem. 2010 Feb 24;58(4):2095-9.
PMID: 20092313 [PubMed - indexed for MEDLINE]
Related citations
2.
Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells.
Lee DS, Lee MK, Kim JH.
Anticancer Res. 2009 Dec;29(12):5039-44.
PMID: 20044614 [PubMed - indexed for MEDLINE]
Related citations
3.
Cell cycle inhibition and apoptosis induced by curcumin in Ewing sarcoma cell line SK-NEP-1.
Singh M, Pandey A, Karikari CA, Singh G, Rakheja D.
Med Oncol. 2009 Oct 27. [Epub ahead of print]
PMID: 19859844 [PubMed - as supplied by publisher]
Related citations
4.
Curcumin disrupts the Mammalian target of rapamycin-raptor complex.
Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S.
Cancer Res. 2009 Feb 1;69(3):1000-8. Epub 2009 Jan 27.
PMID: 19176385 [PubMed - indexed for MEDLINE]Free Article
Related citations
5.
[Changes of nuclear matrix proteins during apoptosis of human osteosarcoma MG-63 cells induced by curcumin]
Li QF, Zheng YB, Yang HB, Shi SL, Zhao ZL, Chen JA.
Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Dec;41(6):473-81. Chinese.
PMID: 19137819 [PubMed - indexed for MEDLINE]
Related citations
6.
Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs.
Angelini A, Iezzi M, Di Febbo C, Di Ilio C, Cuccurullo F, Porreca E.
Oncol Rep. 2008 Oct;20(4):731-5.
PMID: 18813811 [PubMed - indexed for MEDLINE]
Related citations
7.
Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.
Yodkeeree S, Chaiwangyen W, Garbisa S, Limtrakul P.
J Nutr Biochem. 2009 Feb;20(2):87-95. Epub 2008 May 20.
PMID: 18495463 [PubMed - indexed for MEDLINE]
Related citations
8.
Curcumin and cancer: an "old-age" disease with an "age-old" solution.
Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB.
Cancer Lett. 2008 Aug 18;267(1):133-64. Epub 2008 May 6. Review.
PMID: 18462866 [PubMed - indexed for MEDLINE]
Related citations
9.
Cytotoxic effects of curcumin on osteosarcoma cell lines.
Walters DK, Muff R, Langsam B, Born W, Fuchs B.
Invest New Drugs. 2008 Aug;26(4):289-97. Epub 2007 Dec 11.
PMID: 18071634 [PubMed - indexed for MEDLINE]
Related citations
10.
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.
Beevers CS, Li F, Liu L, Huang S.
Int J Cancer. 2006 Aug 15;119(4):757-64.
PMID: 16550606 [PubMed - indexed for MEDLINE]
Related citations
11.
Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.
Kwak HJ, Park MJ, Cho H, Park CM, Moon SI, Lee HC, Park IC, Kim MS, Rhee CH, Hong SI.
Mol Cancer Res. 2006 Mar;4(3):209-20.
PMID: 16547158 [PubMed - indexed for MEDLINE]Free Article
Related citations
12.
Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine.
Huang CY, Chen JH, Tsai CH, Kuo WW, Liu JY, Chang YC.
J Periodontal Res. 2005 Apr;40(2):176-81.
PMID: 15733153 [PubMed - indexed for MEDLINE]
Related citations
13.
Efficacies of plant phenolic compounds on sodium butyrate induced anti-tumour activity.
Indap MA, Barkume MS.
Indian J Exp Biol. 2003 Aug;41(8):861-4.
PMID: 15248485 [PubMed - indexed for MEDLINE]
Related citations
14.
Signal transduction system for interleukin-6 synthesis stimulated by lipopolysaccharide in human osteoblasts.
Kondo A, Koshihara Y, Togari A.
J Interferon Cytokine Res. 2001 Nov;21(11):943-50.
PMID: 11747626 [PubMed - indexed for MEDLINE]
Related citations
15.
Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells.
Kondo A, Mogi M, Koshihara Y, Togari A.
Biochem Pharmacol. 2001 Feb 1;61(3):319-26.
PMID: 11172736 [PubMed - indexed for MEDLINE]
Related citations
16.
Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma.
Navis I, Sriganth P, Premalatha B.
Pharmacol Res. 1999 Mar;39(3):175-9.
PMID: 10094841 [PubMed - indexed for MEDLINE]
Related citations
17.
Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.
Jiang MC, Yang-Yen HF, Yen JJ, Lin JK.
Nutr Cancer. 1996;26(1):111-20.
PMID: 8844727 [PubMed - indexed for MEDLINE]
Related citations
18.
Activity of camptothecin, harringtonin, cantharidin and curcumae in the human tumor stem cell assay.
Jiang TL, Salmon SE, Liu RM.
Eur J Cancer Clin Oncol. 1983 Feb;19(2):263-70.

If dietary curcumin can have a positive influence on cancer prevention and cancer survivors life - then overall incidence of cancers should be really lower in the Asia region (and survival stats would be better), where it widely used as a spice?
Curcumin is the active ingredient of turmeric. It is widely used as a kitchen spice and food colorant throughout India, Asia and the Western world. Curcumin is a major constituent of curry powder. As a complimentary medicine drug it is widely sold at the vitamin sections, millions of dollars are received by its producers in a revenue every year so they should have been able to afford the trials if they wanted to, but...

I found the very recent study from UK
http://www.ncbi.nlm.nih.gov/pubmed/20100380
Br J Nutr. 2010 Jun;103(11):1545-57. Epub 2010 Jan 26.
Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies.
Epstein J, Sanderson IR, Macdonald TT.
Centre for Digestive Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary, University of London, 4 Newark Street, London E1 2AT, UK. j.epstein@qmul.ac.u


I do not have its full text but in the abstract they say that:
"Under some circumstances its effects can be contradictory, with uncertain implications for human treatment."

I found some worrying study re. curcumin already:

http://www.ncbi.nlm.nih.gov/pubmed/19359593
Carcinogenesis. 2009 Jun;30(6):1016-23. Epub 2009 Apr 9.
Lung tumor promotion by curcumin.

Dance-Barnes ST, Kock ND, Moore JE, Lin EY, Mosley LJ, D'Agostino RB Jr, McCoy TP, Townsend AJ, Miller MS.

Department of Cancer Biology, Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
They say that "
curcumin may exhibit organ-specific effects to enhance reactive oxygen species formation in the damaged lung epithelium of smokers and ex-smokers. Ongoing clinical trials thus may need to exclude smokers and ex-smokers in chemopreventive trials of curcumin."
Lung cancer is the epithelial cancer, sarcoma is not, so I do not know what curcumin can do to the established sarcoma lung mets, but this article set the alarm re. use of the curcumin in the lung mets setting.

Thank you both for posting all this information! I have been looking in to curcumin also off the forums and I wil be reading up