Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Silas OA, et al. J Med Case Rep. 2010.

Abstract
INTRODUCTION: Alveolar soft-part sarcomas are rare, slow-growing tumors that metastasize commonly via vascular routes to the lungs, bones, lymph nodes and brain, causing morbidity and mortality. To the best of our knowledge, this is the first case describing metastasis to the liver reported from Nigeria.

CASE PRESENTATION: A 57-year-old man of the Urhobo ethnic group of Nigeria presented with a persistent mass in his left calf. It was initially diagnosed as soft-tissue sarcoma, and its associated systemic effects lead to his death before a histological diagnosis could be obtained.

CONCLUSIONS: Alveolar soft-part sarcoma with metastasis to the liver can occur in our region (northeast Africa), and a high index of suspicion is required to make an early diagnosis, followed by prompt surgical excision with clear margins in order to prevent mortality.

https://www.ncbi.nlm.nih.gov/m/pubmed/20673324/

The histogenesis of alveolar soft part sarcoma: a clinicopathological analysis of 135 cases].
Zhang RY. Zhonghua Bing Li Xue Za Zhi. 1990.
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Abstract
135 cases of alveolar soft part sarcoma (ASPS) are presented. It is the largest series of ASPS currently reported in the medical literature. Follow-up clinical data were available in 51 cases. 68 of the patients were male and 67 were female. The mean age of the patients when making the diagnosis was 35.5 years. Most of the tumors were located at the extremities (72.1%), particularly on the thigh and buttock (36.1%). The five year survival rate was 45.9%, the recurrence rate was 47.1%, and the metastatic rate was 35.3%. The most common sites of metastases were the lung, brain and liver. Microscopially, all the tumors gave a typical organoid structure. Electron microscopic study showed special crystals in the tumor cells. 33 cases of ASPS were examined immunohistochemically with 16 kinds of antibodies in order to clarify the histogenesis of alveolar soft part sarcoma. The presence of desmin, actin, myoglobin and myosin suggests the myogenic character of this tumor.

PMID 2279303 [Indexed for MEDLINE]
Article in Chinese.

https://www.ncbi.nlm.nih.gov/m/pubmed/2279303/