Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Vitamin C administered through IV shows more promise in combating cancer

The potential mechanisms through which treatment with high-dose ascorbic acid may exert its effects on cancer cells have been extensively investigated. Several studies have demonstrated that the in vitro direct cytotoxic effect of ascorbic acid on various types of cancer cells is mediated through a chemical reaction that generates hydrogen peroxide.[1,7] Reviewed in [13,14] Treating colon cancer cells with 2 mM to 3 mM of ascorbic acid resulted in downregulation of specificity protein (Sp) transcription factors and Sp-regulated genes involved in cancer progression.[10] One study suggested that ascorbate-mediated prostate cancer cell death may occur through activation of an autophagy pathway.[6]

In Vito and in clinical trials


http://www.cancer.gov/cancertopics/pdq/ ... ages/Print

Boosting chemo effectiveness-
http://www.m.webmd.com/a-to-z-guides/ne ... ting-power

I know of a patient that did this.. They didn't have asps though.
They are fine now as far as i can remember.
I wish i could remember what they had an stage :/

Found the article on using IV vit C on fatigue after chemo

published Oct 16,2014 from New Brightin Health care--New Zealand

"The effect of intravenous vitamin C on cancer- and chemotherapy- related fatigue and quality of life."


http://journal.frontiersin.org/Journal/ ... .00283/pdf

Free Radic Res. 2005 Jul;39(7):671-86.

Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C.

Duarte TL1, Lunec J.
Author information

Abstract

Vitamin C (or ascorbic acid) is regarded as the most important water-soluble antioxidant in human plasma and mammalian cells which have mechanisms to recycle and accumulate it against a concentration gradient, suggesting that the vitamin might also have important intracellular functions. In this review we summarize evidence from human trials that have attempted an association between vitamin C supplementation and an effect on biomarkers of oxidative DNA damage. Most studies reviewed herein showed either a vitamin C-mediated reduction in oxidative DNA damage or a null effect, whereas only a few studies showed an increase in specific base lesions. We also address the possible beneficial effects of vitamin C supplementation for the prevention of cancer and cardiovascular disease. Finally, we discuss the contribution of cell culture studies to our understanding of the mode of action of vitamin C and we review recent evidence that vitamin C is able to modulate gene expression and cellular function, with a particular interest in cell differentiation.


PMID: 16036346 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/16036346

Dear Debbie,
This is very interesting information and will certainly warrant more research and close following. However, it is very important for all ASPS patients to be sure to discuss with their oncologists any nutritional supplements that they are considering taking, and especially those patients who are receiving systemic treatments because some supplements and foods such as grapefruit can have an adverse affect on the effectiveness of the chemo.
With special caring thoughts and continued Hope,
Bonni

Thank you Bonni
I agree as we need to be aware of conflicting supplements when as patients we are recieving treatments of systemic or other means to treat our ASPS
Besides , I need to keep on task on the studies of intervenous given vitamin C and not ingested / supplemental vitamin C
Thanks for the reminder
Debbie