Vascular endothelial growth factor in soft tissue sarcomas
Posted: Tue Sep 05, 2006 7:11 pm
New article announced on the PubMed published in the Cancer Res. 2006 Sep 1;66(17):8770-8778. by the M.D. Anderson Cancer Center:
Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
They conclude that VEGF is a critical determinant of soft tissue sarcoma (STS) growth and metastasis and that STS chemoresistance is a process induced by the interplay between STS cells and tumor-associated endothelial cells and that STS growth and metastasis can be interrupted by combined low-dose doxorubicin and anti-VEGFR2.
Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: implications for tumor growth, metastasis, and chemoresistance
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
They conclude that VEGF is a critical determinant of soft tissue sarcoma (STS) growth and metastasis and that STS chemoresistance is a process induced by the interplay between STS cells and tumor-associated endothelial cells and that STS growth and metastasis can be interrupted by combined low-dose doxorubicin and anti-VEGFR2.