Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Complete Remission of Lung Metastasis Following Adoptive Immunotherapy Using Activated Autologous γδ T-cells in a Patient with Renal Cell Carcinoma
Abstract. Background: γδ T-cells have recently attracted
considerable attention in the development of novel cancer
immunotherapy, and several different approaches have been
designed and employed in clinical trials. Case Report: A
patient with lung metastasis after radical nephrectomy for
renal cell carcinoma had six cycles of adoptive
immunotherapy using autologous in vitro-activated γδ Tcells
followed by low-dose interleukin-2 and zoledronic acid
intravenous infusion. Complete remission was achieved
which has been maintained for 2 years without any
additional treatment. Immunological analysis demonstrated a
high level of interferon-gamma four hours through one day
following the transfer and peripheral blood γδ T-cells
increased 10-fold from the baseline value, 7 days after the
transfer. No serious adverse events were observed.
Conclusion: Adoptive immunotherapy using γδ T-cells was
shown here to be clinically beneficial and safe, and may
become a therapeutic option for patients with advanced
RCC

The original article is from Tokyo, but according to some additional info from the SA mailing list, Dr. Raymond Chang, NYC has written about this a
while back and offers this off label modality to patients - I am not sure if the treatment is exactly the same, it is not verified by me or anyone on the board.

http://cancerx.wordpress.com/2009/02/23 ... for-cancer

He states that it is a very simple infusion procedure done once a month.

Very cool. But IL-2 can be pretty toxic.