Brain met in renal cell cancer responding to sunitinib

[Olga]

It may be important for our patients with no treatment options for the recurrent/big/multiple/unresectable brain mets:

There is a first article to report that sunitinib is able to cross a the blood-brain barrier and lead to a shrinkage of the brain mets.

Brain metastasis in renal cell cancer responding to sunitinib.
http://www.ncbi.nlm.nih.gov/pubmed/18214028
From the abstract:

The efficacy of the drug in patients with brain metastases has not been explored, since patients with cerebral lesions were excluded in those studies. Thus, we believe that accumulating evidence from personal experience or limited reports could be useful. Moreover, in our case, sunitinib was found to be safe, leading to considerable shrinkage of the brain metastasis without any serious adverse events or central nervous system toxicities.