New article from the head of Department of Thoracic and Vascular Surgery, University Hospital Antwerp, Antwerp, Belgium, Peter Van Schil (we spoken about him on the old discussion board in the connection with his pioneer work to develop the procedure of the isolated lung perfusion for chemoresistant unresectable sarcoma lung mets to deliver high dose chemo directly to the mets - he still works on it), his new very interesting publication is about the fact that highly angiogenic primary tumours can give rise to non-angiogenic metastases. This type of metastasis may be resistant to antiangiogenic therapy:
Distinct angiogenic and non-angiogenic growth patterns of lung metastases from renal cell carcinoma.
http://www.ncbi.nlm.nih.gov/sites/entre ... d_RVDocSum
pubmed id 17727477
non-angiogenic metastases
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Fictional
I just noticed this post, Olga. From what I could see of published studies documenting ASPS, there are different levels of angiogenesis. At an early stage, mets may be able to parasitize neighboring blood vessls without much need to grow in additional ones. To get big, they may need more blood supply (and growth factors).
The findings might also suggest that anti-angiogenesis factors could keep lung mets from getting too big or destructive. The abstract did note that the more invasive tumors in the lung had more blood vessels and endothelial cells.
The findings might also suggest that anti-angiogenesis factors could keep lung mets from getting too big or destructive. The abstract did note that the more invasive tumors in the lung had more blood vessels and endothelial cells.