Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Neutrophil-Lymphocyte Ratio as a Prognostic Parameter in NSCLC Patients Receiving EGFR-TKIs: A Systematic Review and Meta-Analysis

Abstract
Objective. To research the impact of neutrophil-lymphocyte ratio (NLR) as a prognostic parameter in non-small-cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Methods. We searched the databases such as the American Society of Clinical Oncology (ASCO), EMBASE, PubMed, the European Society of Medical Oncology (ESMO), Wanfang, and CNKI for articles illustrating the impact of pretreatment NLR on survival data in NSCLC patients undergoing EGFR-TKIs treatment. We did a meta-analysis for overall survival (OS) and progression-free survival (PFS). Results. We recruited 10 studies in our meta-analysis. Our study suggested that patients with low NLR had better PFS (hazard ratio (HR) = 1.67, 95% confidence interval (CI) = (1.16–2.39), and value = 0.005) and OS (HR = 1.66, 95% CI = (1.08–2.55), and value = 0.02) in comparison to patients with high NLR. Conclusion. In conclusion, our meta-analysis revealed that lower NLR predicted a better survival (PFS and OS) in patients receiving the treatment of EGFR-TKIs.




https://www.hindawi.com/journals/jo/2021/6688346/

I am not sure if the lower NLR predicted a better survival specifically in regards of the TKI treatment and has any connection to that treatment at all, because the lower NLR predicted a better survival overall independently from the treatment type or even disease (cancer, covid, etc). Higher neutrophils and lower lymphocytes are the problem in any disease it seems, and should be the treatment target by themselves - people should try to reduce the inflammatory state of their bodies, it is damaging.