Obviously, antibiotics should be used when indicated, such as for sepsis and other bacterial infections, but we are suggesting that antibiotics should be avoided if there is no clear indication for them,” said investigator Uqba Khan, MD, of NewYork-Presbyterian Hospital/ Weill Cornell Medicine, in New York City. “The results of our study provide an association between the use of antibiotics and inferior outcomes from immunotherapy,” Dr. Khan said. “However,” he added, “we don’t know whether antibiotics somehow directly cause inferior outcomes from immunotherapy or whether there are other factors involved, as well. This question needs to be further explored.”
“Rationale for Study
There is emerging evidence that the gut microbiome may influence antitumor immune response during treatment with checkpoint inhibitors. The use of antibiotics is among factors that can cause gut microbiome dysbiosis, he said.”
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