Cure Alveolar Soft Part Sarcoma International (iCureASPS)

My moms family side greys early , in 20s so I thought this to be interesting . : )
Especially when patients have this side affect with the useage of TKIs.

https://www.sciencedaily.com/releases/2 ... 142934.htm

RESEARCH ARTICLE
A direct link between MITF, innate immunity, and hair graying

https://journals.plos.org/plosbiology/a ... io.2003648

http://mentalfloss.com/article/61452/10 ... -gray-hair


How Hair Turns Gray

Hair grows in a follicle, a bulb-like tube on your scalp. The average head has 100,000 to 150,000 follicles, each operating independently from the others. Hair in its basic, unpigmented state is white. It gets its color from melanin, a pigment that also determines skin color. Two types of melanin, eumelanin (dark brown or black) and phaeomelanin (reddish yellow), combine to make all the hair colors. One hypothesis for why hair goes gray is that aging slows or stops the hair from accessing the melanin, so it comes out gray, silver, or white instead.

Hair May Bleach Itself From The Inside Out

2. New research reveals that graying may be from a build-up of hydrogen peroxide in the hair cell, which causes the hair to bleach itself on the inside. Cells naturally have a small amount of hydrogen peroxide in them, but it’s kept in check by an enzyme called catalase, which converts the hydrogen peroxide to oxygen and water. As we age, the body produces less catalase, so the hydrogen peroxide builds up and, according to the New York Times, blocks “the normal synthesis of melanin, the natural pigment in hair.” Thus the hair turns gray, giving new meaning to the phrase “peroxide blonde.”

3. Graying Is Caused By Heredity

When you’re born, your genes are already hardwired for when and how your hair will turn gray. This includes premature graying—people who gray before age 30 usually do so because it runs in the family. For most of us, graying starts in middle age. Dermatologists go by the 50/50/50 rule of thumb: by age 50, half the population will have at least 50 percent gray hair—although a worldwide survey showed that number was much lower, with only 6 to 23 percent of people half gray by age 50.

4. Race Is Also A Factor

In a related matter, race also determines when you’re likely to gray. In general, Caucasians gray in their mid-30s, Asians in their late-30s, and African Americans in their 40s.