Factsheets-on-Biomarkers/Microsatellite-Instability-Defective-DNA-Mismatch-Repair
Posted: Mon Jan 01, 2018 7:33 am
This link is an excellent and informative resource on MSI and dMMR explanations .
The index
The index
http://oncologypro.esmo.org/Education-L ... tch-RepairIndex
Microsatellite instability (MSI) indicates a defective mismatch repair (dMMR) system
DNA mismatch repair
Microsatellites
Definition of MSI/dMMR tumour
Clinical significance of MSI-dMMR
MSI testing to detect dMMR
MSI molecular test
Immunohistochemistry (IHC)
Choice of test
Confounding definitions of MSI in the literature of the last two decades
Hereditary cancer syndromes associated with MSI cancers
MSI in different sporadic cancer types
Sporadic gastrointestinal cancers
Sporadic gynaecological cancers
Sporadic hepatic, pancreatic and biliary tract cancers
Sporadic skin tumours and melanoma
Other sporadic cancers
MSI and immunotherapy
Conclusions:
References