Thyroid hormone stimulates PD-1/PD-L1in tumors

[Olga]

PD-L1 and PD-1 gene expression are both stimulated by thyroid hormone in cancer cells
https://www.omicsonline.org/proceedings ... 63406.html

"We have shown that thyroid hormone (L-thyroxine, T4) at physiological concentrations acts non-genomically to stimulate cancer cell proliferation, to block apoptosis and to stimulate tumor-related angiogenesis. We report here that T4 stimulates PD-L1 gene expression by a mechanism that is initiated at the cell surface receptor for T4 on the extracellular domain of plasma membrane integrin αvβ3."

I added this subject to a Diet topic of the board with the naturally lowering thyroids strategies (or rather how to avoid increasing it).