First CAR-T therapy success in solid tumors in mice

[Ivan]

In CAR-T therapy, T cells are removed from a patient and modified so that they express receptors specific to the patient's particular cancer. The T cells, which can then recognize and kill the cancer cells, are reintroduced into the patient.

Yesterday, the first successful treatment of a solid tumor via this method (in this case, it was prostate cancer) was reported - Poseida Therapeutics Presents Preclinical Solid Tumor Data for P-PSMA-101 at the American Association for Cancer Research Prostate Cancer Meeting

http://poseida.com/wp-content/uploads/2 ... BS-002.pdf

This is only two steps away from an ASPS cure.

1) The above needs to be done for humans instead of mice.
2) The T-Cells need to be modified to target the known ASPS mutations instead of the above.

When it's available, it will likely cost between $100K-$1M. CAR-T therapies that are currently available are around $500K USD - http://www.onclive.com/web-exclusives/n ... ll-therapy

Save up..

[Ivan]

Actually, there's more stuff with CAR-T relevant to ASPS that's going on right now. ASPS tumors express MET, and there's a clinical trial right now which is testing just that in humans with breast cancer - https://clinicaltrials.gov/ct2/show/NCT03060356

Here are preliminary results of from the same team of a Phase 0 experiment in humans - http://cancerimmunolres.aacrjournals.or ... 9.full.pdf

Basically they injected the CAR-T cells into tumors directly and that worked as expected.

Seems like we're close to having targeted ASPS therapies.

[Ivan]

Here's a good overview of the current state of CAR-T therapy in solid tumors (attached full article).

Chimeric antigen receptor-T cell therapy for solid tumors require new clinical regimens - https://www.ncbi.nlm.nih.gov/pubmed/29048935

A couple more years at least, it seems

[D.ap]

Ivan,

This is indeed good news as FDA has already approved CAR-T for * blood cancers and has moved onto solid tumor research.

ALL- Acute Lymphoblastic Leukemia--see next post **

CAR T-Cell Therapy Approved for Some Children and Young Adults with Leukemia

https://www.cancer.gov/news-events/canc ... d-leukemia


Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®)–Patient Version

General Information About Childhood Acute Lymphoblastic Leukemia
Risk Groups for Childhood Acute Lymphoblastic Leukemia
Treatment Option Overview
Treatment Options for Childhood Acute Lymphoblastic Leukemia
To Learn More About Childhood Acute Lymphoblastic Leukemia
About This PDQ Summary
View All Sections
General Information About Childhood Acute Lymphoblastic Leukemia

https://www.cancer.gov/types/leukemia/p ... atment-pdq

[D.ap]

** ALL- Acute Lymphoblastic Leukemia

(ALL) with glioblastoma multiforme and ALL with alveolar soft part sarcoma (ASPS) ( first case in CMMR-D spectrum) respectively.[2]

http://www.cureasps.org/forum/viewtopic ... lar#p10710

[Ivan]

Furthermore, they are already well on their way to making it work in human prostate cancer -

https://globenewswire.com/news-release/ ... eting.html

Solid tumors is a major milestone. Yes, it's effective in leukemia but that isn't of much help to us.