“When it comes to cancer treatment, many doctors use chemotherapy to stop or slow the growth of a tumor. However, new research presented in the journal Nature suggests that certain types of chemo that aim to put cancers into a so-called sleep state may not be as effective as once thought, Medical News Today reports.
The Vienna-based study focused on a cancer-fighting phenomenon known as senescence, in which cancer cells essentially go to sleep after chemotherapy is used to damage their DNA beyond repair (instead of killing the cancer outright, like other types of chemo). The process was discovered more than 50 years ago and until recently was thought to induce a state of irreversible growth arrest for malignant tumors, meaning that the cells remain in place but stop growing.
But now scientists say they may have discovered why in certain cases, this sleep state may actually provide a fertile area for cancer stem cells to grow in the body — which could pave the way for tumors to metastasize, or grow back and spread.”
https://www.cancerhealth.com/article/pu ... may-enough
Putting Cancer Cells to Sleep May Not Be Enough
Re: Putting Cancer Cells to Sleep May Not Be Enough
5th paragraph from above article-
“However, researchers say that over time, these senescent cancer cells started to resemble cancer stem cells, a phenomenon known as stemness. It is thought that this stemness may have the potential to promote cancer in the body — specifically by expressing genes known as p21 and p24 that are vital for maintaining stem cell functions.”
What are Stem Cells?
By The MNT Editorial Team Last updated Wed 19 Jul 2017
Stem cells are a class of undifferentiated cells that are able to differentiate into specialized cell types. Commonly, stem cells come from two main sources:
“Embryos formed during the blastocyst phase of embryological development (embryonic stem cells) and
Adult tissue (adult stem cells).
Both types are generally characterized by their potency, or potential to differentiate into different cell types (such as skin, muscle, bone, etc.).”
https://www.medicalnewstoday.com/info/stem_cell
Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species*
http://www.cureasps.org/forum/viewtopic.php?f=3&t=1538
“However, researchers say that over time, these senescent cancer cells started to resemble cancer stem cells, a phenomenon known as stemness. It is thought that this stemness may have the potential to promote cancer in the body — specifically by expressing genes known as p21 and p24 that are vital for maintaining stem cell functions.”
What are Stem Cells?
By The MNT Editorial Team Last updated Wed 19 Jul 2017
Stem cells are a class of undifferentiated cells that are able to differentiate into specialized cell types. Commonly, stem cells come from two main sources:
“Embryos formed during the blastocyst phase of embryological development (embryonic stem cells) and
Adult tissue (adult stem cells).
Both types are generally characterized by their potency, or potential to differentiate into different cell types (such as skin, muscle, bone, etc.).”
https://www.medicalnewstoday.com/info/stem_cell
Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species*
http://www.cureasps.org/forum/viewtopic.php?f=3&t=1538
Debbie