Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Posted: **Sat Feb 04, 2017 7:11 am**

Written in 2003 of microsatellite instability in a group of ASPS patients .

Furthermore, microsatellite instability (MSI) analysis and loss of heterozygosity (LOH) on chromosome 5q analysis were used for some cases of ASPS where DNA derived from normal tissue was available

https://www.ncbi.nlm.nih.gov/m/pubmed/14562278/

Posted: **Sat Feb 04, 2017 7:33 am**

Johannes mentioned in a conversation back in feb of 2016

"MSI-high would have been needed to get into this Pembrolizumab trial: https://clinicaltrials.gov/ct2/show/NCT ... bec&rank=7 (one of the inclusion criteria "for any other advanced solid tumor" being that it is Microsatellite Instability (MSI)-High)."

Granted the trial is predominately cancer patients

http://www.cureasps.org/forum/viewtopic ... lity#p9002.

Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma

Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma

Re: Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarc