Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Excellent news Ivan !!
Thanks for checking in.

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“ Myeloid cells are a type of immune cell that play a crucial role in the immune response, and they express various glycoproteins that can serve as ligands for carbohydrate-binding receptors, influencing immune signaling and function. These glycoproteins are important for processes such as ...

“ Myeloid cells are a type of immune cell that play a crucial role in the immune response, and they express various glycoproteins that can serve as ligands for carbohydrate-binding receptors, influencing immune signaling and function. These glycoproteins are important for processes such as ...

“Epitope spreading is a process where the immune response expands to recognize additional epitopes beyond the original target, often occurring during chronic infections or autoimmune diseases. Glycoproteins , which are proteins with carbohydrate groups attached, can serve as antigens that trigger ...

“ Understanding Th2 Cells in Bone Metastasis
Role of Th2 Cells
Th2 cells, a subtype of T helper cells, play a significant role in the immune response, particularly in promoting antibody production and regulating allergic responses. In the context of cancer, including bone metastasis, Th2 cells can ...

“ Th2 cells are a type of immune cell that can play a role in the tumor microenvironment, including in conditions like alveolar soft part sarcoma (ASPS). Research suggests that the immune response, including the activity of Th2 cells, may influence the behavior and progression of ASPS, although the ...

Contribution of immune cells to bone metastasis pathogenesis


Abstract

Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is ...

From the link above

“ Section snippets

Case report

An overweight 23-year-old female presented with a 1-month history of back pain. Her past medical history was noncontributory. The physical exam was unremarkable. Her laboratory values demonstrated an elevated C-reactive protein of 24 mg/L, and ...

“ While eosinophilia can be a marker for these cancers, it is important to note that elevated eosinophil levels can also result from non-cancerous conditions, such as allergies and parasitic infections. Therefore, a thorough medical evaluation is necessary to determine the underlying cause of ...

Eosinophils play a crucial role in the immune response to cancer and can influence the effectiveness of immunotherapy. Higher eosinophil counts have been associated with better responses to immune checkpoint inhibitors in certain cancer patients, indicating their potential as a predictive biomarker ...

Epitope spreading refers to the process where an immune response broadens from a specific target to additional epitopes, which can complicate autoimmune diseases and contribute to the failure of immune therapies. This phenomenon can hinder the effectiveness of treatments by allowing the immune ...

Abstract
Lactate, the end product of glycolysis, efficiently functions as the carbon source, signaling molecules and immune regulators. Lactylation, being regulated by lactate, has recently been confirmed as a novel contributor to epigenetic landscape, not only opening a new era for in-depth ...

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Hello Nino
Good to hear from you and your success!
Thanks for the information on the gene mutation.

Thought I’d share what I saw folks that may be predispositioned to the mutation.



“The UGT1A1*6 mutation is most common in those of East Asian ancestry (15%), and uncommon in people of African (0.1 ...