Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Constitutional (germline) vs somatic (tumour) variants https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/constitutional-germline-vs-somatic-tumour-variants/#:~:text=Key%20messages-,Constitutional%20(also%20known%20as%20germline)%20variants%20are%20present%20in%20all,not%20passed%20on%20...

Hello again Nino ,

Does your blood work report bilirubin values?
Did you by chance have jaundice as a baby?

Hello Nino, It’s good to hear from you.☺️ Your recent happenings with the inflammation from the treated brain lesion , sounds quite scary . However it sounds like your team addressed it quite quickly and successfully. Our son had to undergo LITT for a frontal lobe treated lesion , after it was SRS t...

Bump

Hello You were able to email Dr.Rolle and or his co-worker ? I don’t believe Dr.Rolle is still practicing, but I bet the office could refer you to who you need to contact and what information they would need to assess ie scans etc . Phone: 0049 (0)3523 – 65 102 Fax: 0049 (0)3523 – 65 103 E-mail: pro...

Role of autophagy in cancer prevention Abstract Macroautophagy (autophagy hereafter) is a catabolic process by which cells degrade intracellular components in lysosomes. This cellular garbage disposal and intracellular recycling provided by autophagy serves to maintain cellular homeostasis by elimi...

It is interesting that even in a such a small population disease such a good quality research is done, we are so grateful that there are scientists out there that care about out case...Clinical trials targeting GPNMB with glembatumumab vedotin (Glycoprotein NMB Antibody-Drug Conjugate) are underway...

Ie : GPNMB Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data https://cureasps.org/forum/viewtopic.php?f=2&t=1407&p=16332&hilit=GPNMB#p16332 Modeling Alveolar Soft Part Sarcoma Unveils Novel Mechanisms of Metas...

Mimicking angiogenic microenvironment of alveolar soft-part sarcoma in a microfluidic coculture vasculature chip Significance The in vitro model of alveolar soft-part sarcoma (ASPS) comprehensively mimicked the complex angiogenesis ASPS environment with abundant pericytes-rich and perfusable vascula...

Non-mutational neoantigens in disease Abstract The ability of mammals to mount adaptive immune responses culminating with the establishment of immunological memory is predicated on the ability of the mature T cell repertoire to recognize antigenic peptides presented by syngeneic MHC class I and II m...

https://www.google.com/search?q=p53+mutation+and+autoimmune+disease&client=safari&sca_esv=708ca891a389fdf3&sca_upv=1&hl=en-us&ei=1FPiZpugOsHBp84PoP6A0Q4&oq=p53+mutation+and+autoi&gs_lp=EhNtb2JpbGUtZ3dzLXdpei1zZXJwIhZwNTMgbXV0YXRpb24gYW5kIGF1dG9pKgIIADIFECEYoAEyBRAhGKABMgU...

Don't talk to me of fame and fortune Don't tell me of the things you've read Don't get involved in games of reason There ain't no reason I could see for you to win [Chorus] I've asked you questions now for far too long I'm feelin' highly wasted but there ain't no sun I'm tired of callin' you here wh...

“The cyclin D1-mediated secretion of pro-tumorigenic immuno-miRs and piRNAs may contribute to breast tumor initiation and progression. By up-regulating CTNNB1 and CCND1, PIWIL2 can promote cell cycle and proliferation in tumor cells. Cyclin D1 expression and novel mutational findings in Rosai-Dorfma...

https://cureasps.org/forum/viewtopic.php?f=2&t=1390&p=10710&hilit=Constitutional# Oncologist report Dear Editor, DNA mismatch repair (MMR) is a system for recognizing and repairing errors, which occur during DNA replication and recombination. Biallelic deleterious germline mutations in M...