Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment Xiao-xiao Sun and Qiang Yu

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Article information
Acta Pharmacol Sin. 2015 Oct; 36(10): 1219–1227.
Published online 2015 Sep 21. doi: 10.1038/aps.2015.92


Abstract
Recent studies have revealed extensive genetic and non-genetic variation across different geographical regions of a tumor or throughout different stages of tumor progression, which is referred to as intra-tumor heterogeneity. Several causes contribute to this phenomenon, including genomic instability, epigenetic alteration, plastic gene expression, signal transduction, and microenvironmental differences. These variables may affect key signaling pathways that regulate cancer cell growth, drive phenotypic diversity, and pose challenges to cancer treatment. Understanding the mechanisms underlying this heterogeneity will support the development of effective therapeutic strategies.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648179/

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"Understanding tumor heterogeneity may be the next big quest in cancer science, as differences between cells within a tumor can have important consequences for how cancers are diagnosed and treated."


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