There is a new very fascinating article from the Department of Radiation Oncology, The University of Virginia Health Sciences Center, Charlottesville, Virginia. They found that Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day.
Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: Is there a difference in outcome between morning and afternoon treatment?
http://www.ncbi.nlm.nih.gov/pubmed/20830691
If anyone is planning a Gamma Knife treatment for their brain mets, try to negotiate the earlier time, as ASPS is a very radioresistant disease overall.
Gamma knife radiosurgery done morning versus afternoon
Re: Gamma knife radiosurgery done morning versus afternoon
I felt it important to bump this topic as it is so very very important for a patient and their caretakers to be informed .
I found another great article to add to this post as well. :)
https://lungcancer.net/living/circadian ... =sovj9l65m
Olga has constantly encouraged the timing of radiation treatments according to our more “vulnerable “circadian rhythm down time , to possibly overpower our radio-resistant sarcoma .
Thank you Olga and all ,for what you’ve brought to light on all of our rare sarcoma to date !
I found another great article to add to this post as well. :)
https://lungcancer.net/living/circadian ... =sovj9l65m
Olga has constantly encouraged the timing of radiation treatments according to our more “vulnerable “circadian rhythm down time , to possibly overpower our radio-resistant sarcoma .
Thank you Olga and all ,for what you’ve brought to light on all of our rare sarcoma to date !
Debbie
Re: Gamma knife radiosurgery done morning versus afternoon
Circadian characteristics of permissive and suppressive effects of cortisol and their role in homeostasis and the acute inflammatory response
Abstract
In this work we explore a semi-mechanistic model that considers cortisol’s permissive and suppressive effects through the regulation of cytokine receptors and cytokines respectively. Our model reveals the proactive role of cortisol during the resting period and its reactive character during the body’s activity phase. Administration of an acute LPS dose during the night, when cortisol’s permissive effects are higher than suppressive, leads to increased cytokine levels compared to LPS administration at morning when cortisol’s suppressive effects are higher. Interestingly, our model presents a hysteretic behavior where the relative predominance of permissive or suppressive effects results not only from cortisol levels but also from the previous states of the model. Therefore, for the same cortisol levels, administration of an inflammatory stimulus at cortisol’s ascending phase, that follows a time period where cytokine receptor expression is elevated ultimately sensitizing the body for the impending stimulus, leads to higher cytokine expression compared to administration of the same stimulus at cortisol’s descending phase.
Keywords: Cortisol suppressive effects, cortisol permissive effects, cytokine circadian rhythms, inflammatory response
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306649/
Abstract
In this work we explore a semi-mechanistic model that considers cortisol’s permissive and suppressive effects through the regulation of cytokine receptors and cytokines respectively. Our model reveals the proactive role of cortisol during the resting period and its reactive character during the body’s activity phase. Administration of an acute LPS dose during the night, when cortisol’s permissive effects are higher than suppressive, leads to increased cytokine levels compared to LPS administration at morning when cortisol’s suppressive effects are higher. Interestingly, our model presents a hysteretic behavior where the relative predominance of permissive or suppressive effects results not only from cortisol levels but also from the previous states of the model. Therefore, for the same cortisol levels, administration of an inflammatory stimulus at cortisol’s ascending phase, that follows a time period where cytokine receptor expression is elevated ultimately sensitizing the body for the impending stimulus, leads to higher cytokine expression compared to administration of the same stimulus at cortisol’s descending phase.
Keywords: Cortisol suppressive effects, cortisol permissive effects, cytokine circadian rhythms, inflammatory response
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306649/
Debbie