Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression?

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Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression?


Radiation injury
Three distinct types of radiation injury are recognized and can be identified on the basis of the time of presentation: acute (during or shortly after radiation), subacute or early-delayed (typically up to 12 weeks after radiation), and late (months to years after completion of radiation) [1]. A complete understanding of the pathophysiology of CNS injury after RT is lacking, however, it is clear that multiple variables are relevant to its occurrence, including total dose, fraction size, time between fractions, treatment volume and concurrent chemotherapy [2–8].


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325371/