Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Combining radiotherapy and ipilimumab induces clinically relevant radiation-induced abscopal effects in metastatic melanoma patients: A systematic review


Highlights
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Radiotherapy plus ipilimumab increases abscopal responses in metastatic melanoma patients.

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Radiotherapy plus ipilimumab improves the OS in metastatic melanoma patients.

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Radiotherapy plus ipilimumab does not increase toxicity in metastatic melanoma patients.



https://www.sciencedirect.com/science/a ... 0817300782

Abstract
Background

In the last years, limited studies have described that radiotherapy could produce important distant responses in unirradiated sites, the so-called “abscopal effect”. Recent evidence suggests that radiotherapy induces antigen release from tumor, in this way activating the immune system. However, radiotherapy alone is rarely enough to induce the systemic response requested for control of the metastases. With the advent of immunotherapy, the immune checkpoint inhibitors (ICI) have demonstrated impressive efficacy in various metastatic cancers. Currently, preclinical and clinical studies have reported a significant increase of abscopal responses in patients treated with the combination of radiotherapy and ICI. The purpose of this review was summarizing the clinical studies combining radiotherapy and ipilimumab (ipi), particularly focusing on abscopal responses.