Cure Alveolar Soft Part Sarcoma International (iCureASPS)

Thanks, Debbie. The latest MRI was compared to an MRI from last year (we know that comparing CTs and MRIs would be difficult!). Johannes Certainly ☺️ The reason I ask if there was prior treatment and or treatments, to the femur is that in our experience those treatments can be exasperated by an ICI...

Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance 15 May 2019 Abstract Immune-checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte antigen 4 (CTLA-4), anti-programmed cell death 1 (PD-1) and anti-programmed cell death 1 ligand 1 (PD-L1) antibod...

Dermatologic toxicities to immune checkpoint inhibitor therapy: A review of histopathologic features Abstract Antineoplastic agents that utilize the immune system have revolutionized cancer treatment. Specifically, implementation of immune checkpoint inhibitors, monoclonal antibodies that block cyto...

Hello Johannes,
What kinds of increases are you seeing on the femur , from
the ct scan to the mri?
Was there any prior treatments to the femur ?

The trial involving asps patients from USA and Canada of durvalumab and Tremelimumab..

https://cureasps.org/forum/viewtopic.php?p=10748#p10748

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors Abstract Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients experienc...

Hi Cindy,
So this 3xinfusion equals 9 weeks or 12 weeks ?
How’s the leg radiation area looking, as far as irritation etc ?
I wonder if Sam needs some time to recoup before embarking on any more immune suppressive treatments? How’s his weight ?

https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-595 The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies. Abstract Background The historical basis and contemporary evidence for the use of immune strategies for preven...

Hello Bonni and family, I’m wondering how Brittany’s seizures etc are doing these days? I was searching on cediranib through the forum and came upon a post I did back in 2016 in reference to cediranib and the study of biomarkers in giloblastoma Using the combination of blood work, and Mri to see the...

Hello Johannes and Elisa Joshua’s covid severity was quite minimal as far as symptoms,feeling tired and slight headache,. How well did Elisa weather the Covid virus? Did she by chance take Paxlovid? Anytime a person embarks on a medication that is needed,Of course, immune suppression happens. So as ...

Hello Johannes and Elisa, I’m so glad the heart met responded to the Atezolizumab + Bevacizumab combination. Plan bs are always a must , huh . Especially with ASPS ! Is the lung tumor unable to be surgically removed or are you all concerned about having to stop treatment if you all had surgery perfo...

Lactate and Ketone Bodies Act as Energy Substrates as Well as Signal Molecules in the Brain Abstract Astroglia or astrocytes, the most abundant cells in the brain, are interposed between neuronal synapses and the microvasculature in the brain’s gray matter. This unique anatomical location allows ast...

https://bmcbiol.biomedcentral.com/artic ... 017-0392-4

Listen to pronunciation. (MA-kroh-fayj) A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cell

Tissue macrophages: heterogeneity and functions Abstract Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes within the body, not only as phagocyte...

Hello, Hope everyone is good.I know it’s been a long time here.A lot of successes for fellow asps warriors n some losses too.Well,as known it’s been 6 years that Im on Votrient(tki),which had been showing stability.But a lot of things changed meanwhile.Well few ppl might know my journey but would j...